General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter TACR1 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0717C3)
The PathHunter TACR1 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of TACR1 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged TACR1. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting TACR1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Vector Biolabs Retinoid X receptor beta Adenovirus (Ad-RXRb)
Ready to use in vivo grade AAV and Adenovirus Ready to use in vivo grade AAV and Adenovirus pre synthesized DNA vector High titer viral vectors 1/EA
American Research Products Inc PrEST Antigen CLK2
PrEST Antigen CLK2 antigen APrEST85735 for CDC-like kinase 2 Recombinant protein fragment of Human CLK2
Biochain Institute Inc Frozen Tissue Section - Arrhythmia, infarct: Heart, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Biochain Institute Inc Frozen Tissue Section - Congestive Heart Failure: Heart, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Electron Microscopy Sciences Dual Geological Thin Section Holder, 9.5 mm Pin
This thin section holder made from aluminum with copper clips and brass screws. The unit measures 55x58x8 mm and it holds two standard geological thin sections or slides of 47 x 27 mm. The holder has convenient tweezer inserts which allow for easy loading. Clips are provided for secure holding.
Type: 9.5 mm Pin
Eurofins Discoverx Ready-to-Assay EP4 Prostanoid Receptor Frozen Cells, 2 Vials of Cells. (HTS142LRTA)
The Ready-to-Assay EP4 Prostanoid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. prostaglandin E2) based activation of PTGER4 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGER4 alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGER4, the resulting calcium activity can be assayed in either detection mode. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Invivogen A549 LUNG CARCINOMA CELLS EXPR
A549 lung carcinoma cells expressing human ACE2 and human TMPRSS2
Eurofins Discoverx ChemiScreen FFAR3/GPR41 Free Fatty Acid Receptor Stable Cell Line, 2 vials. (HTS135C)
The ChemiScreen FFAR3/GPR41 Free Fatty Acid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. free fatty acids) based activation of FFAR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses FFAR3 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of FFAR3, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay FFA3/GPR41 Free Fatty Acid Receptor Frozen Cells, 2 Vials of Cells. (HTS135RTA)
The Ready-to-Assay FFA3/GPR41 Free Fatty Acid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. free fatty acids) based activation of FFAR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses FFAR3 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of FFAR3, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
ATCC ST486; Burkitt's Lymphoma; Human (Homo sapiens)
ST486 is a B lymphocyte cell that was isolated from the ascites of a Burkitt's lymphoma female patient. This cell line was deposited by IT Magrath and can be used in immunology research.
Eurofins Discoverx ChemiBrite EP3 Prostanoid Receptor Stable Cell Line, 2 vials. (HTS092L)
The ChemiBrite EP3 Prostanoid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin E2) based activation of PTGER3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGER3 alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGER3, the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx PathHunter RXFP3 Total Internalization U2OS Cell Line, 2 vials. (93-0948C3)
The PathHunter RXFP3 Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of RXFP3 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged RXFP3 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the RXFP3 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Chlamydia trachomatis; Serovar I; Strain: UW-12/Ur
Chlamydia trachomatis serovar I strain UW-12/Ur is propagated in McCoy [McCoy B] cells (ATCC CRL-1696). This strain was isolated from the urethra of a male with non-gonococcal urethritis and it has applications in sexually transmitted disease research.
ATCC Staphylococcus aureus; subsp. aureus
Staphylococcus aureus subsp. aureus strain HDE288 is a methicillin-resistant bacterium that was isolated from the pneumology ward of a hospital in Lisbon, Portugal. This strain has applications in antimicrobial resistance research, drug development, and infectious disease research.